(N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid

(N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid - Names and Identifiers

Name	N-benzyl-N-(tert-butoxycarbonyl)glycine
Synonyms	OTAVA-BB 1403921 N-Boc-N-benzyl-glycine N-BENZYL-N-(TERT-BUTOXYCARBONYL)GLYCINE N-benzyl-N-(tert-butoxycarbonyl)glycine N-Benzyl-N-(tert-butoxycarbonyl)glycine 2-(BENZYL(TERT-BUTOXYCARBONYL)AMINO)ACETIC ACID (N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid Glycine, N-[(1,1-dimethylethoxy)carbonyl]-N-(phenylmethyl)- tert-Butyl N-(2-hydroxy-2-oxoethyl)-N-(phenylmethyl)carbamate
CAS	76315-01-0
InChI	InChI=1/C14H19NO4/c1-14(2,3)19-13(18)15(10-12(16)17)9-11-7-5-4-6-8-11/h4-8H,9-10H2,1-3H3,(H,16,17)

(N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid - Physico-chemical Properties

Molecular Formula	C14H19NO4
Molar Mass	265.3
Density	1.17g/cm³
Boling Point	409.491°C at 760 mmHg
Flash Point	201.453°C
Vapor Presure	0mmHg at 25°C
Storage Condition	2-8°C
Refractive Index	1.535

(N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid - Risk and Safety

Hazard Class

IRRITANT

(N-benzyl-N-tert-butoxycarbonyl)aminoacetic acid - Introduction

N-benzyl-N-(tert-butoxycarbonyl)glycine is an organic compound whose structure is N-benzyl-D-glycine modified by a Boc protecting group. The following is a description of the nature, use, method and safety information of N-benzyl-N-(tert-butoxycarbonyl)glycine:

Nature:
-Appearance: White or off-white crystalline powder
-Molecular formula: C15H19NO4
-Molecular weight: 281.32g/mol
-Melting point: about 90-95 degrees Celsius (can vary due to the crystalline nature of the sample)
-Solubility: Soluble in some organic solvents, such as ethanol, formic acid, dichloromethane

Use:
- N-benzyl-N-(tert-butoxycarbonyl)glycine is a commonly used amino acid derivative, widely used in the field of organic synthesis.
-It is often used as a protecting group (Boc protecting group) or synthetic intermediate for active molecules in drug synthesis.
-It can be used as a modeling unit for amino acids to study the structure and function of proteins.

Preparation Method:
- N-benzyl-N-(tert-butoxycarbonyl)glycine can be prepared by reacting N-benzyl-D-glycine with Boc2O (tert-butoxycarbonyl chloride).
-At room temperature, N-benzyl-D-glycine is reacted with Boc2O to generate N-benzyl-N-(tert-butoxycarbonyl)glycine, which is purified by crystallization to obtain the product.

Safety Information:
- N-benzyl-N-(tert-butoxycarbonyl)glycine is less toxic, but as a chemical substance, it still needs to be handled properly.
-It may cause irritation to the eyes, skin and respiratory tract, so care should be taken to avoid direct contact during operation.
-Follow proper laboratory safety practices during use, such as wearing appropriate personal protective equipment (e. g. gloves, face mask).
-During storage, the N-benzyl-N-(tert-butoxycarbonyl)glycine should be kept dry, avoiding high temperature and light to prevent decomposition and degradation of the compound.

Last Update：2024-04-09 20:49:11